Resources for experimentally validated miRNA targets

DIANA-TarBase v7.0

Additional Info

  • Activitiy Active
  • Description
    DIANA-TarBase v.7 indexes more than half a million miRNA:gene interactions have been curated from published experiments implemented utilizing 356 different cell types from 24 species. This database identifies positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment.
  • Main feature The largest collection of validated manually analyzed miRNA targets
  • Unique features
    Indexing more than half a million experimentally supported
    miRNA:mRNA interactions for 24 species which derived from
    specific, as well as high throughput experiments
    Interconnected with other DIANA-Lab tools, as
    DIANA-microT which enable to extend validated
    interaction with predicted information
  • Organism Human, Mouse, Other vertebrates, Insects, Nematodes, Plants, Rat
  • Category Experimentally validated miRNA targets
  • Last observe Monday, 29 August 2016
  • Year published 2006
  • Citations per year 35.7
  • Last update Thursday, 06 November 2014
  • Updated over past 3 years Yes
  • Relative Popularity 579395

miRecords

Additional Info

  • Activitiy Active
  • Description
    miRecords is a resource for animal miRNA-target interactions. The Validated Targets component is a large, high-quality database of experimentally validated miRNA targets resulting from meticulous literature curation. The Validated Targets component of miRecords hosts 2705 records of interactions between 644 miRNAs and 1901 target genes in 9 animal species.
  • Main feature Presenting validated targets along with 11 various prediction algorithms
  • Unique features
    The only database that present both validated and predicted targets together
    2705 records of interactions between 644 miRNAs and 1901 target genes in 9 animal species
  • Organism Human, Mouse, Other vertebrates, Insects, Nematodes, Rat
  • Category Experimentally validated miRNA targets
  • Other covered categories
    Composite target prediction
  • Last observe Monday, 29 August 2016
  • Year published 2009
  • Citations per year 82.86
  • Last update Saturday, 27 April 2013
  • Updated over past 3 years No
  • Relative Popularity 3131127

Starbase v2.0

Additional Info

  • Activitiy Active
  • Description
    starBase v2.0 systematically identify the RNA–RNA and protein–RNA interaction networks from 108 CLIP-Seq (PAR-CLIP, HITS-CLIP, iCLIP, CLASH) data sets generated by 37 independent studies. By analyzing millions of RNA-binding protein binding sites, we identified ∼9000 miRNA-circRNA, 16 000 miRNA-pseudogene and 285 000 protein–RNA regulatory relationships.
  • Main feature Deciphering Protein-RNA and miRNA- target interactions
  • Unique features
    Finding lncRNAs, miRNAs, competing endogenous RNAs(ceRNAs),
    RNA-binding proteins (RBPs) interactions in 6 species
    Based on CLIP-Seq (HITS-CLIP, PAR-CLIP, iCLIP, CLASH) data
  • Organism Human, Mouse, Plants
  • Category Experimentally validated miRNA targets
  • Other covered categories
    miRNA function
    miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2011
  • Citations per year 46.2
  • Last update Saturday, 09 November 2013
  • Updated over past 3 years Yes
  • Relative Popularity 14384

miRTarBase

Additional Info

  • Activitiy Active
  • Description
    miRTarBase has accumulated more than three hundred and sixty thousand miRNA-target interactions (MTIs), which are collected by manually surveying pertinent literature after NLP of the text systematically to filter research articles related to functional studies of miRNAs. Generally, the collected MTIs are validated experimentally by reporter assay, western blot, microarray and next-generation sequencing experiments. miRTarBase provides comparison with other similar, previously developed databases.
  • Main feature experimentally validated microRNA– target interactions
  • Unique features
    Containing 4966 articles, 7439 strongly validated MTIs
    (using reporter assays or western blots) and 348 007 MTIs from CLIP-seq from 18 species
  • Organism Human, Mouse, Other vertebrates, Insects, Viruses, Nematodes, Plants, Rat
  • Category Experimentally validated miRNA targets
  • Last observe Saturday, 03 September 2016
  • Year published 2011
  • Citations per year 100
  • Last update Tuesday, 15 September 2015
  • Updated over past 3 years Yes
  • Relative Popularity 23082

miRWalk 2.0

Additional Info

  • Activitiy Active
  • Description
    miRWalk2.0 is supplying the biggest available collection of predicted and experimentally verified miRNA-target interactions with various novel and unique features. It documents experimentally verified miRNA-target interaction information collected via an automated text-mining search and data from existing resources (miRTarBase, PhenomiR, miR2Disease and HMDD) that offer such information.
  • Main feature Tool of validated gene-miRNA interactions
  • Unique features
    Confirmed miRNA interactions associated with genes, pathways, organs, diseases and transcription factors.
    Validated miRNA interactions information on cell lines
  • Organism Human, Mouse, Rat
  • Category Experimentally validated miRNA targets
  • Other covered categories
    Composite target prediction
    miRNA expression
    miRNA roles in diseases
    miRNA interactions in pathways
  • Last observe Thursday, 01 September 2016
  • Year published 2011
  • Citations per year 124.2
  • Last update Tuesday, 21 April 2015
  • Updated over past 3 years Yes
  • Relative Popularity 15843