Resources of miRNA roles in various diseases

miR2Disease

Additional Info

  • Activitiy Active
  • Description
    miR2Disease, a manually curated database, aims at providing a comprehensive resource of microRNA deregulation in various human diseases. Around one-seventh of the microRNA-disease relationships represent the pathogenic roles of deregulated microRNA in human disease. Each entry in the miR2Disease contains detailed information on a microRNA-disease relationship, including a microRNA ID, the disease name, a brief description of the microRNA-disease relationship, an expression pattern of the microRNA, the detection method for microRNA expression, experimentally verified target gene(s) of the microRNA and a literature reference.
  • Main feature miRNA-disease relationship
  • Unique features
    Search by miRNA ID, disease name or target gene.
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Thursday, 01 September 2016
  • Year published 2009
  • Citations per year 59.43
  • Last update Wednesday, 02 April 2008
  • Updated over past 3 years No
  • Relative Popularity 11077573

HMDD

Additional Info

  • Activitiy Active
  • Description
    HMDD the Human microRNA Disease Database is a database that curated experiment-supported evidence for human microRNA and disease associations. Each entry in HMDD v1.0 has four items for annotation; they are miRNA name, disease name, the reference PubMed ID, and the evidence supporting the miRNA-association from the original paper.
  • Main feature miRNA and disease association
  • Unique features
    Contain miRNA names, disease names, dysfunction evidences, and the literature PubMed ID
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Thursday, 01 September 2016
  • Year published 2008
  • Citations per year 27.5
  • Last update Wednesday, 15 October 2008
  • Updated over past 3 years No
  • Relative Popularity 0

CAMi-Finder

Additional Info

  • Activitiy Active
  • Description
    CAMi-Finder is a resource for human cancer miRNA associations. It provides two types of functionalities: first, Showing all the validated cancer-miRNA relationship with a mouse-click and second, Predicts novel cancer-miRNA relationships by mining predicted miRNA-target genes Targetminer, TargetScan, miRanda , PITA and TargetSpy.
  • Main feature Cancer miRNA associations
  • Unique features
    Search by cancer type or miRNA
    Mining of customized associations between cancer causing microRNAs
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Monday, 29 August 2016
  • Year published 2003
  • Last update Friday, 31 December 2010
  • Updated over past 3 years No
  • Relative Popularity 122569

dbDEMC

Additional Info

  • Activitiy Active
  • Description
    "dbDEMC is expected to be a valuable source for identification of cancer-related miRNAs, thereby helping with the improvement of classification, diagnosis and treatment of human cancers. This database collected the miRNA expression profiles of 14 cancer types, curated from 48 microarray data sets in peer-reviewed publications. The Significance Analysis of Microarrays method was used to retrieve the miRNAs that have dramatically different expression levels in cancers when compared to normal tissues. A total of 607 differentially expressed miRNAs (590 mature miRNAs and 17 precursor miRNAs) were obtained in the current version of dbDEMC.
  • Main feature Differentially expressed miRNAs in cancers
  • Unique features
    Search by miRNA ID
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Thursday, 01 September 2016
  • Year published 2010
  • Citations per year 5.33
  • Last update Thursday, 02 December 2010
  • Updated over past 3 years No
  • Relative Popularity 0

mirdsnp

Additional Info

  • Activitiy Active
  • Description
    miRdSNP is a database of manually curated dSNPs on the 3'UTRs of human genes from available publications in PubMedThe advanced web interface allows users to perform proximity searches between miRNA target sites and dSNPs by gene name, miRbase ID, target prediction algorithm, disease, and any nucleotide distance between dSNPs and miRNA target sites. The web interface displays detailed sequence views showing the relationship between dSNPs, miRNA target sites, and SNPs. An interactive visualization tool shows the chromosomal distribution of dSNPs, miRNA target sites (from TargetScan), and SNPs.
  • Main feature Disease- related SNPs
  • Unique features
    Disease-associated SNPs and miRNA target sites on 3′UTRs of mRNAs
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Monday, 29 August 2016
  • Year published 2012
  • Citations per year 12.25
  • Last update Tuesday, 01 March 2011
  • Updated over past 3 years No
  • Relative Popularity 11682

miRo v 2.0

Additional Info

  • Activitiy Active
  • Description
    miRò is a web-based knowledge base that provides users with miRNA-phenotype associations in humans. It integrates data from various online sources, such as databases of miRNAs, ontologies, diseases and targets, into a unified database equipped with an intuitive and flexible query interface and data mining facilities. The main goal of miRò analysis through sophisticated mining techniques and the introduction of a new layer of associations between genes and phenotypes inferred based on miRNAs annotations.
  • Main feature Associations between miRNAs and diseases
  • Unique features
    miRNA relations to disease concluded from their validated and predicted targets
    Based on miRanda, PicTar, TargetScan and miRecords algorithms
  • Organism Human
  • Category miRNA roles in diseases
  • Other covered categories
    Composite target prediction
    miRNA function
  • Last observe Wednesday, 31 August 2016
  • Year published 2009
  • Citations per year 3.57
  • Last update Wednesday, 24 June 2009
  • Updated over past 3 years No
  • Relative Popularity 46199

miRSel

Additional Info

  • Activitiy Active
  • Description
    The microRNA-gene association database miRSel combines text-mining results with existing databases and computational predictions. Text mining enables the reliable extraction of microRNA, gene and protein occurrences as well as their relationships from texts. Thereby, we increased the number of human, mouse and rat miRNA-gene associations by at least three-fold as compared to e.g. TarBase, a resource for miRNA-gene associations.
  • Main feature Links between miRNAs and genes
  • Unique features
    Extracting associations between miRNAs and genes from the biomedical literatures
  • Organism Human, Mouse, Rat
  • Category miRNA roles in diseases
  • Last observe Monday, 29 August 2016
  • Year published 2010
  • Citations per year 6.33
  • Last update Tuesday, 16 March 2010
  • Updated over past 3 years No
  • Relative Popularity 60512

miRTRAP

Additional Info

  • Activitiy Inactive
  • Description
    miRTRAP incorporates the mechanisms of miR biogenesis and includes additional criteria regarding the prevalence and quality of small RNAs arising from the antisense strand and neighboring loci. This program was applied to the simple chordate Ciona intestinalis and identified nearly 400 putative miR loci.
  • Main feature Connection of miRNA and disease
  • Unique features
    Functional analyses of disease-related miRNAs from high throughput sequencing data
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Monday, 29 August 2016
  • Year published 2010
  • Citations per year 8.17
  • Last update Tuesday, 06 April 2010
  • Updated over past 3 years No
  • Relative Popularity 1830

miRWalk 2.0

Additional Info

  • Activitiy Active
  • Description
    miRWalk2.0 is supplying the biggest available collection of predicted and experimentally verified miRNA-target interactions with various novel and unique features. Information on miRNA-target interactions on 2,035 disease ontologies, 6,727 Human Phenotype ontologies and 4,980 OMIM disorders is available.
  • Main feature miRNA and disease associations
  • Unique features
    Based on predicted and validated results
    98,887 relationships on 1572 miRNAs from human, mouse and rat linked to 691 diseases
  • Organism Human, Mouse, Rat
  • Category miRNA roles in diseases
  • Other covered categories
    Composite target prediction
    Experimentally validated miRNA targets
    miRNA expression
    miRNA interactions in pathways
  • Last observe Thursday, 01 September 2016
  • Year published 2011
  • Citations per year 124.2
  • Last update Tuesday, 21 April 2015
  • Updated over past 3 years Yes
  • Relative Popularity 15864

MMIA

Additional Info

  • Activitiy Active
  • Description
    MMIAs is microRNA and mRNA integrated analysis that integrates microRNA and mRNA expression data with predicted microRNA target information for analyzing microRNA-associated phenotypes and biological functions. To assign biological relevance to the integrated microRNA/mRNA profiles, MMIA uses exhaustive human genome coverage, including various disease-associated genes as well as conventional canonical pathways and Gene Ontology.
  • Main feature Linking miRNA functions to diseases
  • Unique features
    Biological and pathological causes and effects of the expression
    Using TargetScan, PITA and PicTar algorithms
  • Organism Human
  • Category miRNA roles in diseases
  • Other covered categories
    Target prediction correlated with expression data
  • Last observe Thursday, 01 September 2016
  • Year published 2009
  • Citations per year 12.71
  • Last update Tuesday, 14 April 2009
  • Updated over past 3 years No
  • Relative Popularity 0

PhenomiR

Additional Info

  • Activitiy Active
  • Description
    The PhenomiR database provides information about differentially regulated miRNA expression in diseases and other biological processes. The content of PhenomiR is completely generated by manual curation of experienced annotators. The PhenomiR database provides data from 542 studies that investigate deregulation of microRNA expression in diseases and biological processes as a systematic, manually curated resource. Using the PhenomiR dataset, depending on disease type, independent information from cell culture studies contrasts with conclusions drawn from patient studies.
  • Main feature miRNA and disease relations
  • Unique features
    Differentially expressed miRNAs in biological processes and diseases
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Monday, 29 August 2016
  • Year published 2010
  • Citations per year 13.83
  • Last update Tuesday, 15 February 2011
  • Updated over past 3 years No
  • Relative Popularity 236828

PolymiRTS 3

Additional Info

  • Activitiy Active
  • Description
    Polymorphisms in microRNAs and their target sites (PolymiRTS) are known to disrupt miRNA function, leading to the development of disease and variation in physiological and behavioral phenotypes. PolymiRTS database is an integrated platform for analyzing the functional impact of genetic polymorphisms in miRNA seed regions and miRNA target sites. Recent advances in genomic technologies have made it possible to identify miRNA-mRNA binding sites from direct mapping experiments such as CLASH (cross linking, ligation and sequencing of hybrids).
  • Main feature linking miRNA polymorphism and diseases
  • Unique features
    Relating microRNA and target sites polymorphisms to diseases and traits
  • Organism Human, Mouse
  • Category miRNA roles in diseases
  • Last observe Friday, 26 August 2016
  • Year published 2014
  • Citations per year 25
  • Last update Monday, 07 October 2013
  • Updated over past 3 years Yes
  • Relative Popularity 78346

S-MED

Additional Info

  • Activitiy Active
  • Description
    Sarcoma microRNA Expression Database S-MED is a repository that describes the patterns of miRNA expression in various human sarcoma types. S-MED provides both basic and advanced data search options for exploration of the data in heat map and text/numerical formats. The database also provides statistical details such as fold changes and P-values for differentially expressed miRNAs in each sarcoma type and corresponding normal tissue.
  • Main feature miRNA profile in sarcoma
  • Unique features
    SExpression profiles for over 300 tumor tissue samples representing 22 different sarcoma types
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Friday, 02 September 2016
  • Year published 2010
  • Citations per year 8.67
  • Last update Friday, 11 December 2009
  • Updated over past 3 years No
  • Relative Popularity 3217

SomamiR DB 2.0

Additional Info

  • Activitiy Active
  • Description
    SomamiR 2.0 is a database of cancer somatic mutations in microRNAs (miRNA) and their target sites that potentially alter the interactions between miRNAs and competing endogenous RNAs (ceRNA) including mRNAs, circular RNAs (circRNA) and long noncoding RNAs (lncRNA). We expanded the scope of the database by including somatic mutations that impact the interactions between miRNAs and two classes of non-coding RNAs, circRNAs and lncRNAs.
  • Main feature Somatic mutations and microRNA targeting in cancer
  • Unique features
    determine the effect of somatic mutations on miRNA function in cancer
    Somatic mutations in miRNA or miRNA target site
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Wednesday, 31 August 2016
  • Year published 2013
  • Citations per year 8.33
  • Last update Wednesday, 28 October 2015
  • Updated over past 3 years Yes
  • Relative Popularity 78346

HMDD v2.0

Additional Info

  • Activitiy Active
  • Description
    Human microRNA Disease Database, HMDD v2.0, is a collection of experimentally supported human microRNA and disease associations. In the updated database, miRNA-disease association data were annotated in more details. For example, miRNA-disease association data from genetics, epigenetics, circulating miRNAs and miRNA-target interactions were integrated into the database. In addition, HMDD v2.0 presented more data that were generated based on concepts derived from the miRNA-disease association data, including disease spectrum width of miRNAs and miRNA spectrum width of human diseases.
  • Main feature miRNA and disease link
  • Unique features
    Contain miRNA-disease association data from genetics, epigenetics, circulation samples and miRNA-target interactions
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Thursday, 01 September 2016
  • Year published 2014
  • Citations per year 27.5
  • Last update Tuesday, 14 January 2014
  • Updated over past 3 years Yes
  • Relative Popularity 6329120

miRcancer

Additional Info

  • Activitiy Active
  • Description
    miRCancer provides comprehensive collection of microRNA (miRNA) expression profiles in various human cancers which are automatically extracted from published literatures in PubMed. It utilizes text mining techniques for information collection. Manual revision is applied after auto-extraction to provide 100% precision. User can search the database by miRNA and/or cancer names in the miRCancer Search page. Our website also provides two sequence analysis tools: clustering and chi-square analysis which can perform analysis on all or selected pool of miRNA sequences.
  • Main feature MicroRNA cancer association 
  • Unique features
    Search by miRNA or cancer name
    Containing sequence analysis based on cancer or species
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Thursday, 01 September 2016
  • Year published 2013
  • Citations per year 21
  • Last update Wednesday, 22 June 2016
  • Updated over past 3 years Yes
  • Relative Popularity 21385

Starbase v2.0

Additional Info

  • Activitiy Active
  • Description
    StarBase v2.0 systematically identify the RNA–RNA and protein–RNA interaction networks. starBase is designed for decoding Pan-Cancer and Interaction Networks of lncRNAs, miRNAs, competing endogenous RNAs(ceRNAs), RNA-binding proteins (RBPs) and mRNAs from large-scale CLIP-Seq (HITS-CLIP, PAR-CLIP, iCLIP, CLASH) data and tumor samples (14 cancer types, >6000 samples).
  • Main feature Deciphering Pan-Cancer Networks of lncRNAs, miRNAs, ceRNAs and RNA-binding proteins
  • Unique features
    Clinical and expression profiles of 14 cancer types (>6000 samples)
    Networks of CLIP-Seq experimentally supported miRNA-lncRNA and miRNA-mRNA interactions
  • Organism Human
  • Category miRNA roles in diseases
  • Other covered categories
    Experimentally validated miRNA targets
    miRNA function
  • Last observe Thursday, 01 September 2016
  • Year published 2011
  • Citations per year 46.2
  • Last update Wednesday, 11 September 2013
  • Updated over past 3 years Yes
  • Relative Popularity 14004

YM500v2

Additional Info

  • Activitiy Active
  • Description
    YM500 is an integrated database for miRNA quantification, isomiR identification, arm switching discovery and novel miRNA prediction from small RNA sequencing (smRNA-seq). In this update of YM500, we focus on the cancer miRNAome to make the database more disease-orientated. There are more than 8,000 cancer-related smRNA-seq datasets (including those of primary tumours, paired normal tissues, PBMC, and metastatic tissues) incorporated into YM500v2.
  • Main feature cancer miRNAom
  • Unique features

    Including 8,000 cancer-related smRNA-seq datasets
    Including primary tumors, paired normal tissues, PBMC, and metastatic tissues

  • Organism Human
  • Category miRNA roles in diseases
  • Other covered categories
    miRNA expression
  • Last observe Saturday, 03 September 2016
  • Year published 2013
  • Citations per year 7.33
  • Last update Wednesday, 29 October 2014
  • Updated over past 3 years Yes
  • Relative Popularity 89820

CREAM

Additional Info

  • Activitiy Active
  • Description
    CREAM (Chemotherapy ResistancE-Associated MiRSNP Database) is a database depositing the functional miRSNP associated with chemotherapy resistance. The term miRSNP was coined and defined as a novel class of functional single nucleotide polymorphisms (SNPs) that can interfere with microRNA (miRNA) function and result in loss of miRNA regulation of target gene. Various evidences have supported that miRSNPs play significant roles in regulating chemotherapy resistance.
  • Main feature Chemotherapy resistance-associated MiRSNP
  • Unique features
    Functional miRSNP associated with chemotherapy resistance
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Wednesday, 31 August 2016
  • Year published 2014
  • Citations per year 1.5
  • Last update Thursday, 29 May 2014
  • Updated over past 3 years Yes
  • Relative Popularity 0

CHNmiRD

Additional Info

  • Activitiy Active
  • Description
    CHNmiRD is a web-based tool for inferring novel miRNA-disease associations based on a complex heterogeneous network (CHN) involving 402 miRNAs and 5080 diseases. CHNmiRD integrates multiple genomic and phenotype data, including protein-protein interaction data, gene ontology data, experimentally verified miRNA-target relationships, disease phenotype information and known miRNA-disease connections.
  • Main feature Novel miRNA-disease associations
  • Unique features
    based on a complex heterogeneous network (CHN) involving 402 miRNAs and 5080 diseases
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Monday, 29 August 2016
  • Year published 2016
  • Citations per year 0
  • Last update Friday, 05 February 2016
  • Updated over past 3 years Yes
  • Relative Popularity 9443984

DMD

Additional Info

  • Activitiy Active
  • Description
    The Dietary microRNA Database is a searchable database of published and novel microRNA sequences discovered in human food. Each entry in the database represents the mature sequence of a food-born microRNA and may be retrieved along with its information about the genomic location and hairpin sequence of the parental pre-microRNA. The annotation covers the hairpin structure of the pre-microRNAs, cross-species sequence comparison on each mature microRNA, reported disease relevance, and the experimentally validated gene targets, of which a gene regulation network was built for each entry.
  • Main feature Dietary microRNA
  • Unique features
    Novel microRNA sequences discovered in human food
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Friday, 02 September 2016
  • Year published 2015
  • Citations per year 4
  • Last update Sunday, 15 February 2015
  • Updated over past 3 years Yes
  • Relative Popularity 10064

EpimiRBase

Additional Info

  • Activitiy Active
  • Description
    EpimiRBase is a manually curated database for researchers interested in the role of microRNAs in epilepsy. The fully searchable database includes information on up- and down-regulated microRNAs in the brain and blood, as well as functional studies, and covers both rodent models and human epilepsy.
  • Main feature MicroRNA-epilepsy associations
  • Unique features
    Information on up and downregulated microRNAs in the brain and blood and functional studies
    Covers rodent models and human epilepsy
  • Organism Human, Mouse, Rat
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2016
  • Citations per year 0
  • Last update Friday, 17 June 2016
  • Updated over past 3 years Yes
  • Relative Popularity 24365542

ExcellmiRDB

Additional Info

  • Activitiy Active
  • Description
    ExcellmiRDB provides integrated information about miRNAs levels in biofluids in a user-friendly way. ExcellmiRDB is the only one specialized for storing curated data on miRNA levels in biofluid samples. At present, ExcellmiRDB has 2773 disease-extracellular miRNAs and 1108 biofluid-extracellular miRNAs relationships curated from 108 articles selected from more than 600 surveyed PubMed abstracts.
  • Main feature Extracellular miRNAs
  • Unique features
    miRNA-disease associations along with expression pattern and number of articles
    Network visualize miRNA body fluid associations
  • Organism Rat
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2015
  • Citations per year 3
  • Last update Monday, 01 June 2015
  • Updated over past 3 years Yes
  • Relative Popularity 0

MicroSNiPer

Additional Info

  • Activitiy Active
  • Description
    MicroSNiPer predicts the impact of a SNP on putative microRNA targets. This application interrogates the 3'-untranslated region and predicts if a SNP within the target site will disrupt/eliminate or enhance/create a microRNA binding site. MicroSNiPer computes these sites and examines the effects of SNPs in real time.
  • Main feature SNP effects on putative microRNA targets
  • Unique features
    Search by gene or SNP
  • Organism Human, Mouse
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2010
  • Citations per year 10.67
  • Last update Thursday, 07 October 2010
  • Updated over past 3 years Yes
  • Relative Popularity 14805

miRandola

Additional Info

  • Activitiy Active
  • Description
    miRandola is a manually curated database of circulating miRNAs. The database catalogs information from both published (from literature and public resources) and unpublished studies (from direct researchers submission). The database include information about miRNAs and their extracellular form, samples, fluids and data sources.
  • Main feature Circulating non-coding RNAs in diseases
  • Unique features
    Extracellular/Circulating non-coding RNAs
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Friday, 02 September 2016
  • Year published 2012
  • Citations per year 16
  • Last update Friday, 19 October 2012
  • Updated over past 3 years Yes
  • Relative Popularity 38451

miRNA SNiPer

Additional Info

  • Activitiy Inactive
  • Description
    miRNA SNiPer is an online tool for the detection of miRNA polymorphisms in vertebrates and generated a catalog of miRNA seed region polymorphisms (miR-seed-SNPs) consisting of 149 SNPs in six species. Although a majority of detected polymorphisms were due to point mutations, two consecutive nucleotide substitutions were also identified in nine miRNAs.
  • Main feature miRNA polymorphisms in vertebrates
  • Unique features
    Accepts a list of miRNA genes and returns a table of variations in pre-miRNA, mature, seed region
  • Organism Mouse, Other vertebrates, Rat
  • Category miRNA roles in diseases
  • Last observe Wednesday, 31 August 2016
  • Year published 2012
  • Citations per year 7.25
  • Last update Sunday, 15 February 2015
  • Updated over past 3 years Yes
  • Relative Popularity 0

MirSNP

Additional Info

  • Activitiy Active
  • Description
    MirSNP is a collection of human SNPs in predicted miRNA-mRNA binding sites. We identified 414,510 SNPs that might affect miRNA-mRNA binding. Annotations were added to these SNPs to predict whether a SNP within the target site would decrease/break or enhance/create a miRNA-mRNA binding site
  • Main feature Polymorphisms altering miRNA target sites
  • Unique features
    Search by gene, mRNA, miRNA or SNP
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2012
  • Citations per year 15
  • Last update Friday, 23 November 2012
  • Updated over past 3 years Yes
  • Relative Popularity 100469

Mirsnpscore

Additional Info

  • Activitiy Active
  • Description
    Mirsnpscore is a computational tool that can help identifying SNPs associated with diseases, by focusing on SNPs affecting miRNA-regulation of genes. The tool predicts the effects of SNPs in miRNA target sites and uses linkage disequilibrium to map these miRNA-related variants to SNPs of interest in GWAS. We compared our predicted SNP effects in miRNA target sites with measured SNP effects from allelic imbalance sequencing. Our predictions fit measured effects better than effects based on differences in free energy or differences of TargetScan context scores.
  • Main feature SNP effects on microRNA targeting
  • Unique features
    Search by gene, miRNA or SNP
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Friday, 02 September 2016
  • Year published 2011
  • Citations per year 6.2
  • Last update Tuesday, 21 June 2011
  • Updated over past 3 years Yes
  • Relative Popularity 28473

multiMiR

Additional Info

  • Activitiy Active
  • Description
    multiMiR is a comprehensive collection of predicted and validated miRNA-target interactions and their associations with diseases and drugs. multiMiR collecting nearly 50 million records from 14 different databases. Expansion of databases based on disease annotation and drug response, in addition to many experimental and computational databases.
  • Main feature miRNA and disease relations
  • Unique features
    Using 11 predicted and validate miRNA-target Interactions
    Expansion of databases to those based on disease annotation and drug microRNA response
  • Organism Human, Mouse
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2014
  • Citations per year 4.5
  • Last update Thursday, 24 July 2014
  • Updated over past 3 years Yes
  • Relative Popularity 19836

OncomiRDB

Additional Info

  • Activitiy Active
  • Description
    OncomiRDB database aiming at annotating the experimentally verified oncogenic and tumor-suppressive miRNAs from literature. This database only collects items having direct functional evidences: 1) the miRNA regulates at least one cancer-related phenotype or cellular process (such as proliferation, apoptosis, migration and invasion, senescence and cell cycle regulation); or 2) the miRNA directly regulates at least one oncogenic or tumor-suppressive gene verified by luciferase reporter assay.
  • Main feature Experimentally verified oncogenic and tumor-suppressive miRNAs
  • Unique features
    miRNA regulates one cancer-related phenotype or cellular process
    miRNA directly regulates one oncogenic or tumor-suppressive gene
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2014
  • Citations per year 7
  • Last update Monday, 06 January 2014
  • Updated over past 3 years Yes
  • Relative Popularity 5736

OncomiRdbB

Additional Info

  • Activitiy Active
  • Description
    OncomiRdbB is a comprehensive database of oncomiRs mined from different existing databases for mouse and humans along with novel oncomiRs that we have validated in human breast cancer samples. The database also lists their respective predicted targets, identified using miRanda, along with their IDs, sequences, chromosome location and detailed description. This database facilitates querying by search strings including microRNA name, sequence, accession number, target genes and organisms.
  • Main feature Linking miRNA and breast cancer
  • Unique features
    Database of miRNAs, targets, their hubs and networks of various pathways which are involved in Breast cancer
    Targets involved in wnt, Jak- Stat, MAPK, mTOR, VEGF, Apoptosis and Notch pathways
  • Organism Human, Mouse
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2014
  • Citations per year 7
  • Last update Wednesday, 15 January 2014
  • Updated over past 3 years Yes
  • Relative Popularity 258012

Patrocles

Additional Info

  • Activitiy Inactive
  • Description
    The Patrocles database compiles DNA sequence polymorphisms (DSPs) that are predicted to perturb miRNA-mediated gene regulation. To support the biological relevance of Patrocles' content, we searched for signatures of selection acting on 'Patrocles single nucleotide polymorphisms (pSNPs)' in human and mice. As expected, we found a strong signature of purifying selection against not only SNPs that destroy conserved target sites but also against SNPs that create novel, illegitimate target sites, which is reminiscent of the Texel mutation in sheep
  • Main feature Linking polymorphisms in miRNA target with human disease
  • Unique features
    Polymorphic miRNA-mediated gene regulation
    Coverage of targets, miRNA precursors and silencing machinery
  • Organism Human, Mouse, Other vertebrates, Rat
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2009
  • Citations per year 12.43
  • Last update Friday, 09 October 2009
  • Updated over past 3 years Yes
  • Relative Popularity 0

SurvMicro

Additional Info

  • Activitiy Active
  • Description
    SurvMicro assesses miRNA signatures from publicly available miRNA profiles using multivariate survival analysis. SurvMicro is composed of a wide and updated database of >40 cohorts in different tissues and a web tool where survival analysis can be done in minutes. We presented evaluations to portray the straightforward functionality of SurvMicro in liver and lung cancer.
  • Main feature Expression of miRNAs in cancers
  • Unique features
    Assessment of miRNA based prognostic signatures for cancer clinical outcomes by multivariate survival analysis
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2014
  • Citations per year 2.5
  • Last update Friday, 09 September 2016
  • Updated over past 3 years Yes
  • Relative Popularity 6916

TMREC

Additional Info

  • Activitiy Active
  • Description
    TMREC integrated curated transcriptional and post-transcriptional regulations to construct the TF and miRNA regulatory network. Next, this database identified all linear paths using the Breadth First Search traversal method. Finally, we used known disease-related genes and miRNAs to measure the strength of association between cascades and diseases. Currently, TMREC consists of 74,248 cascades and 25,194 cascade clusters, involving in 412 TFs, 266 miRNAs and 545 diseases.
  • Main feature Transcription factor and miRNA regulatory cascades in human disease
  • Unique features
    Understand the transcriptional and post-transcriptional regulatory mechanisms in specific disease
    Identify the potential therapeutic targets in the upstream of the cascades
  • Organism Human
  • Category miRNA roles in diseases
  • Last observe Saturday, 03 September 2016
  • Year published 2015
  • Citations per year 2
  • Last update Thursday, 30 October 2014
  • Updated over past 3 years Yes
  • Relative Popularity 0